The purpose of this study was to investigate whether preventive measures such as reduction of exposure and the introduction of the histamine provocation test (HPT) as a selection instrument resulted in a lower incidence of potroom asthma (PA) and a longer time lag between the commencement of employment and the occurrence of PA.
Between 1970 and 1990,179 cases of PA were diagnosed.
This period was divided into three periods.
During period 1 (1970-1975), no exposure data were available.
Period 2 (1976-1981) is characterized by known exposure data obtained by means of fluoride determinations in urine.
At the beginning of period 3 (1982-1990) the HPT was incorporated into the preemployment medical examination.
We computed the incidence density (ID) in the three periods and analyzed the timelag in relation to the year of employment and confounding factors such as age, atopic history, blood eosinophil counts, lung function, smoking habits at preemployment, and exposure level.
After introduction of the preemployment HPT the ID decreased, but cases continued to occur (ID 11.6 in period 2 versus 2.5 in period 3).
The time lag was did not differ when subjects with bronchial hyperresponsiveness were screened out.
The exposure level and an atopic history were factors associated with the period of employment and, therefore, confounded the results. (...)
Mots-clés Pascal : Four pot, Industrie métallurgique, Aluminium, Métal, Exposition professionnelle, Asthme, Toxicité, Prévention, Dépistage, Temps exposition, Pays Bas, Europe, Médecine travail, Homme, Epidémiologie, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Allergie, Immunopathologie
Mots-clés Pascal anglais : Pot furnace, Metallurgical industry, Aluminium, Metal, Occupational exposure, Asthma, Toxicity, Prevention, Medical screening, Exposure time, Netherlands, Europe, Occupational medicine, Human, Epidemiology, Respiratory disease, Obstructive pulmonary disease, Allergy, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0121756
Code Inist : 002B03L05. Création : 22/06/1998.