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  1. Interleukin 1alpha and hematological examination in mechanics exposed to low benzene concentrations.

    Article - En anglais

    Object : To examine the hypothesis of Renz and Kalf relative to the involvement of interleukin 1alpha (IL-1alpha) in the development of anemia in benzene-exposed workers.

    According to this hypothesis, benzene inhibits the cleavage of the IL-1alpha precursor (proIL-1alpha) to mature IL-1alpha and the lack of this cytokine is responsible for benzene-induced bone marrow suppression.

    This inhibition of the processing of proIL-1alpha is attributed to an inhibition of calpain.

    Method 

    Selection of a population of mechanics exposed to low levels of benzene from fuels, assessment of usual exposure and lifetime exposure duration, and measurements of concentrations of workplace-air benzene and urinary benzene metabolites.

    Determination of IL-1alpha concentrations was done by a whole-blood assay after lipopolysaccharide stimulation and a hematological examination was carried out.

    Statistical analysis considered several possible confounding factors. particularly smoking and drinking habits.

    Design 

    Cross-sectional study.

    Results 

    The level of exposure of the mechanics to benzene from fuels was mostly well below I ppm.

    IL-1alpha production was not decreased in mechanics exposed to benzene from fuels, and no correlation between IL-1alpha concentrations and red blood cell counts appeared.

    With the exception of a slight decrease in red blood cell counts in mechanics, no hint of a toxic effect of exposure on hematological parameters was found. (...)

    Mots-clés Pascal : Benzène, Exposition professionnelle, Homme, Toxicité, Mécanisme action, Anémie, Hématologie, Surveillance biologique, Interleukine 1alpha, Cytokine, Fuel oil, Garage commercial, Médecine travail, Hémopathie, Mécanicien

    Mots-clés Pascal anglais : Benzene, Occupational exposure, Human, Toxicity, Mechanism of action, Anemia, Hematology, Biological monitoring, Interleukin 1alpha, Cytokine, Fuel oil, Commercial garage, Occupational medicine, Hemopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0121751

    Code Inist : 002B03L06. Création : 22/06/1998.