Object : To examine the hypothesis of Renz and Kalf relative to the involvement of interleukin 1alpha (IL-1alpha) in the development of anemia in benzene-exposed workers.
According to this hypothesis, benzene inhibits the cleavage of the IL-1alpha precursor (proIL-1alpha) to mature IL-1alpha and the lack of this cytokine is responsible for benzene-induced bone marrow suppression.
This inhibition of the processing of proIL-1alpha is attributed to an inhibition of calpain.
Selection of a population of mechanics exposed to low levels of benzene from fuels, assessment of usual exposure and lifetime exposure duration, and measurements of concentrations of workplace-air benzene and urinary benzene metabolites.
Determination of IL-1alpha concentrations was done by a whole-blood assay after lipopolysaccharide stimulation and a hematological examination was carried out.
Statistical analysis considered several possible confounding factors. particularly smoking and drinking habits.
The level of exposure of the mechanics to benzene from fuels was mostly well below I ppm.
IL-1alpha production was not decreased in mechanics exposed to benzene from fuels, and no correlation between IL-1alpha concentrations and red blood cell counts appeared.
With the exception of a slight decrease in red blood cell counts in mechanics, no hint of a toxic effect of exposure on hematological parameters was found. (...)
Mots-clés Pascal : Benzène, Exposition professionnelle, Homme, Toxicité, Mécanisme action, Anémie, Hématologie, Surveillance biologique, Interleukine 1alpha, Cytokine, Fuel oil, Garage commercial, Médecine travail, Hémopathie, Mécanicien
Mots-clés Pascal anglais : Benzene, Occupational exposure, Human, Toxicity, Mechanism of action, Anemia, Hematology, Biological monitoring, Interleukin 1alpha, Cytokine, Fuel oil, Commercial garage, Occupational medicine, Hemopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0121751
Code Inist : 002B03L06. Création : 22/06/1998.