Ethylene oxide is an alkylating agent known to be a directly acting mutagen and carcinogen.
This study describes the relationship between workplace ambient air concentrations of ethylene oxide and the concentration of N-2-hydroxyethylvaline in the globin of exposed workers.
During the sterilization of medical equipment, 12 workers were occupationally exposed to ethylene oxide.
Personal and stationary ambient air measurements were carried out to monitor the external exposure.
The determination of the protein adducts was based on the N-alkyl-Edman method. introducing a new commercially available dipeptide standard for calibration purposes.
Ethylene oxide concentrations ranging from 0.2 to 8.5 ppm were found in the workplace air.
The adduct concentrations ranged from 5,219 to 32,738 pmol N-2-hydroxyethylvaline/g globin in the case of regularly exposed workers (n=9) and from 518 to 3,321 pmol N-2-hydroxyethylvaline/g globin for three persons with occasional contact with ethylene oxide.
The Deutsche Forschungsgemeinschaft established in 1993 a relationship between the ethylene oxide concentration in ambient air and the amount of N-2-hydroxyethylvaline in human globin.
By extrapolation, constant exposure to I ppm ethylene oxide should yield approximately 4.000 pmol N-2-hydroxyethylvaline/g globin. (...)
Mots-clés Pascal : Oxirane, Carcinogène, Mutagène, Teneur air ambiant, Analyse chimique, Surveillance biologique, Sang, Homme, Exposition professionnelle, Stérilisation thermique, Matériel technique, Adduit moléculaire, Médecine travail
Mots-clés Pascal anglais : Ethylene oxide, Carcinogen, Mutagen, Ambient air concentration, Chemical analysis, Biological monitoring, Blood, Human, Occupational exposure, Heat sterilization, Technical equipment, Molecular adduct, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0121750
Code Inist : 002B03N. Création : 22/06/1998.