Familial clustering of factor VIII and von Willebrand factor levels.
Recently, we found that high levels of clotting factor VIII (>150 (IU/dl) are common and make an important contribution to thrombotic risk.
The determinants of high factor VIII : C are unclear and might be partly genetic.
Therefore, we tested the influence of age, blood group and von Willebrand factor (VWF) levels on factor VIII : C levels, and investigated whether factor VIII : C levels are genetically determined.
We performed an analysis of 564 female relatives of hemophilia A patients, who had visited our center for genetic counseling.
In univariate analysis, AB0 blood group, age and VWF antigen (VWF : Ag) levels all influenced factor VIII : C levels.
After adjustment for the effect of VWF : Ag levels, both blood group and age still had an effect on factor VIII : C levels.
In sister pairs, the Pearson correlation coefficient between factor VIII : C levels was 0.17 (p=0.024) and this correlation remained positive (0.15, p=0.046) after correction for the influence of VWF : Ag.
In mother-daughter pairs, no correlation of factor VIII : C levels was found.
The correlation of VWF : Ag levels in sisterpairs was 0.41 (p<0.001) and in mother-daughter pairs 0.44 (p<0.001), in line with the assumption that VWF : Ag levels are under control of autosomal genes.
Familial influence on plasma factor VIII : C and VWF : Ag levels was investigated with a recently developed familial aggregation test. (...)
Mots-clés Pascal : Thrombose, Artère, Facteur risque, Epidémiologie, Facteur coagulation, Facteur antihémophilique A, Facteur Willebrand, Etude familiale, Déterminisme génétique, Pays Bas, Europe, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie
Mots-clés Pascal anglais : Thrombosis, Artery, Risk factor, Epidemiology, Coagulation factor, Factor VIII, Willebrand factor, Family study, Genetic determinism, Netherlands, Europe, Human, Cardiovascular disease, Vascular disease, Arterial disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0120821
Code Inist : 002B12B03. Création : 22/06/1998.