Changes in IgE-mediated allergy to ubiquitous inhalants after removal from or diminution of exposure to the agent causing occupational asthma.
Background One possibility, among others, for explaining the persistence of asthma symptoms in occupational asthma (OA) after the cessation of exposure to the causal agents may be that subjects become sensitized to ubiquitous inhalants.
Objective The aim of this study was to evaluate the development or increase of IgE-mediated sensitization to ubiquitous allergens, both to high-and low-molecular-weight agents, in 100 subjects with OA after cessation of exposure.
Methods Subjects were evaluated on a first visit, at the time of diagnosis of OA, coinciding with the cessation or diminution of exposure to the causal agent, and on a second visit, 5.8 ± 3.3 years afterwards.
At each visit, a history of ocular, nasal and asthmatic symptoms related to exposure to common allergens was obtained together with spirometry and assessment of bronchial responsiveness to methacholine.
We analysed total IgE and specific IgE to Dermatophagoides farinae.
D. pteronyssinus, birch, ragweed and timothy grass pollens, cat and dog danders, and Alternaria, using enzyme allergosorbent test (EAST) from blood samples taken on each visit.
Results Total IgE levels showed a tendency to diminish.
No changes were found in the number of positive EAST (presence of detectable levels of specific IgE) or in the levels of specific IgE.
Although significantly more symptoms of rhinoconjunctivitis and asthma in contact with house dust (P<0.05) and pets (P<0. (...)
Mots-clés Pascal : Asthme, Exposition professionnelle, Médecine travail, Allergie, IgE, Test radioallergosorbent, Homme, Exploration immunologique, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Immunopathologie
Mots-clés Pascal anglais : Asthma, Occupational exposure, Occupational medicine, Allergy, IgE, Radioallergosorbent test, Human, Immunological investigation, Respiratory disease, Obstructive pulmonary disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0119624
Code Inist : 002B11B. Création : 22/06/1998.