Prospective and cross-sectional studies have demonstrated that bone mass predicts fracture risk.
However, most prospective studies have been limited to a few years of follow-up.
We investigated the long-term associations of bone mass with vertebral fractures using longitudinal data collected from more than 500 postmenopausal Japanese-American women in the Hawaii Osteoporosis Study.
New vertebral fractures were identified during an average of 2.7 years between 1992 and 1995.
Short-term fracture prediction was evaluated using bone mass (spine, calcaneus, distal radius, and proximal radius) measured at the beginning of follow-up.
Long-term prediction was evaluated using bone mass measured before the follow-up period (11 years earlier for nonspine bone mass and 8 years earlier for spine).
All four bone mass measurements were significant predictors of vertebral fractures identified during the subsequent 2.7 years (short-term prediction), with odds ratios (ORs) ranging from 1.5 to 1.9. The ORs for long-term prediction were slightly lower in magnitude, but the confidence intervals overlapped the short-term ORs considerably, suggesting that both long-term and short-term associations are similar in magnitude. (...)
Mots-clés Pascal : Masse osseuse, Prédiction, Fracture, Vertèbre, Etude longitudinale, Postménopause, Japonais, Américain, Prospective, Rachis pathologie, Système ostéoarticulaire pathologie, Homme, Femelle
Mots-clés Pascal anglais : Bone mass, Prediction, Fracture, Vertebra, Follow up study, Postmenopause, Japanese, American, Prospective, Spine disease, Diseases of the osteoarticular system, Human, Female
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0118939
Code Inist : 002B15F. Création : 22/06/1998.