Prevalence, specificity and significance of ovarian antibodies during spontaneous premature ovarian failure.
Autoimmunity may be involved in idiopathic premature ovarian failure (POF).
However, the frequency, physiopathology and potential reversibility of autoimmune oophoritis needs clarification.
Using an ELISA against whole tissue homogenate as antigen, from human ovaries at different ages, positive circulating ovarian antibodies (AOA) were found in 59% of patients with primitive idiopathic POF (27/46) ; 20/27 were positive for IgG isotype, 9/27 for IgM and 8/27 for IgA.
Specificity of AOA was examined (i) by comparison to different control groups ; mean values of the three subclasses of immunoglobins were significantly higher in POF women than in normally cycling fertile young women (n=23) and fertile young men (n=17), in untreated Grave's disease (n=35) or in women with positive antinuclear factor in=25) ; and (ii) by assessing possible cross-reaction ; only six out of the 27 positive sera reacted with other tissues (thyroid, pancreas, adrenal), including four clinical polyendocrinopathies. (...)
Mots-clés Pascal : Autoanticorps, Autoimmunité, Prévalence, Epidémiologie, Ovaire, Anticorps, Physiopathologie, Insuffisance ovarienne, Idiopathique, Ovarite, Appareil génital femelle, Ovaire pathologie, Appareil génital femelle pathologie, Endocrinopathie, Maladie autoimmune, Homme, Femelle
Mots-clés Pascal anglais : Autoantibody, Autoimmunity, Prevalence, Epidemiology, Ovary, Antibody, Pathophysiology, Ovarian failure, Idiopathic, Ovaritis, Female genital system, Ovarian diseases, Female genital diseases, Endocrinopathy, Autoimmune disease, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0116768
Code Inist : 002B20C01. Création : 22/06/1998.