Two case-control studies were set up to investigate the relationship between melanocytic naevi and risk of melanoma and to compare the naevus phenotype in two countries exposed to greatly different levels of sun exposure and different melanoma rates.
In England 117 melanoma cases and 163 controls were recruited from the North-East Thames Region and 183 melanoma cases and 162 controls from New South Wales, Australia.
Each subject underwent a whole-body naevus count performed by the same examiner in each country.
Relative risks associated with melanocytic naevi in each country were calculated with comparison of naevus data in controls between Australia and England.
Atypical naevi were strong risk factors for melanoma in both countries : the odds ratio (OR) for three or more atypical naevi was 4.6 (95% Cl 2.0-10.7) in Australia compared with 51.7 (95% Cl 6.5-408.4) in Engiand.
Common naevi were also significant risk factors in Australia and England with similar odds ratios in the two countries.
Prevalence of atypical naevi was greater in Australian controls than in English controls : OR 9.7 (95% Cl 1.2-81.7) for three or more atypical naevi in Australia compared with England.
For young age groups, the median number of common naevi was greater in Australia than in the UK, whereas for older individuals this difference in naevi number between the two countries disappeared. (...)
Mots-clés Pascal : Mélanome, Peau, Facteur risque, Naevus, Atypique, Rayonnement solaire, Rayonnement UV, Onde électromagnétique, Etude cas témoin, Etude comparative, Epidémiologie, Royaume Uni, Europe, Australie, Océanie, Homme, Tumeur maligne, Peau pathologie
Mots-clés Pascal anglais : Melanoma, Skin, Risk factor, Nevus, Atypical, Solar radiation, Ultraviolet radiation, Electromagnetic wave, Case control study, Comparative study, Epidemiology, United Kingdom, Europe, Australia, Oceania, Human, Malignant tumor, Skin disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0112423
Code Inist : 002B08A. Création : 22/06/1998.