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  1. Effectiveness and cost effectiveness of single bolus treatment with abciximab (Reo Pro) in preventing restenosis following percutaneous transluminal coronary angioplasty in high risk patients.

    Article - En anglais


    To assess the clinical effectiveness and cost effectiveness of abciximab in preventing restenosis after percutaneous transluminal coronary angioplasty (PTCA).

    Design-Data from a previous study, the EPIC trial, were used because only this trial was able to provide event data capable of constructing a cost effectiveness analysis over six months.

    All other study data reviewed supported the findings of the EPIC trial.

    To provide indicative results on long term health outcomes, survival and event-free survival were extrapolated using US epidemiological data in a Markov modelling process.

    Setting and patients-Patients who were at high risk for ischaemic complications after PTCA, treated in the standard manner.

    Interventions-Abciximab was added to the regimen of intravenous heparin and aspirin.


    The EPIC study (n=2099) indicated an 8.1% absolute reduction in serious cardiovascular events (95% confidence interval 3.1% to 12.7%) and a 23% relative risk reduction (p=0.001).

    Based on the six month trial period, the additional cost per patient free from a serious event (Australian dollars) is $13 012 and for a special risk/benefit measure of outcome, the additional cost is $14 243.

    Epidemiological data support extended survival and ischaemic event-free survival with clinically successful PTCA.

    The results of the modelled analysis indicate a cost per additional life-year gained of $5547 and a cost per additional year event-free of $4285. (...)

    Mots-clés Pascal : Dilatation instrumentale, Artère coronaire, Resténose, Analyse coût efficacité, Economie santé, Abciximab, Dose unique, Voie intraveineuse, Chimiothérapie, Traitement, Prévention, Complication, Homme, Efficacité traitement, Inhibiteur thromboagrégation, Traitement instrumental

    Mots-clés Pascal anglais : Instrumental dilatation, Coronary artery, Restenosis, Cost efficiency analysis, Health economy, Abciximab, Single dose, Intravenous administration, Chemotherapy, Treatment, Prevention, Complication, Human, Treatment efficiency, Antiplatelet agent, Instrumentation therapy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0111178

    Code Inist : 002B02G. Création : 22/06/1998.