To investigate the effects of current obesity, steady weight change and weight fluctuation on physical functioning and (ii) to determine whether associations are independent of coronary heart disease.
Prospective cohort study with body mass index (BMI) measurements at four time points between the ages of 25 and 63y.
British civil servants based in London offices at baseline.
6895 men and 3413 women aged 35-55y at baseline.
Physical functioning was assessed using the 10-item scale from the Short Form 36 Health Survey, with a score in the lowest quartile indicating poor physical functioning.
After adjustment for age and confounders (employment grade, smoking, alcohol, exercise and menopausal status), current BMI was monotonically associated with poor physical functioning in women whereas a threshold effect at a BMI of 27 kg/m2 was seen in men.
The odds ratio of poor physical functioning was 1.55 (95% confidence interval (Cl) 1.02-2.35) amongst women and 1.04 (95Ya Cl 0.77-1.41) amongst men with BMI 23-24.9 kg/m2 compared to those with BMI<21kg/m. Women in the upper, compared to the lower, tertile of steady weight change, had an odds ratio of poor physical functioning of 1.79.
(1.24-2.601 after adjustment for age, confounders, current BMI and weight fluctuation. Women in the upper, compared to the lower, tertile of weight fluctuation had an odds ratio of poor physical functioning of 1.70 (1. (...)
Mots-clés Pascal : Obésité, Poids corporel, Fluctuation, Facteur prédictif, Exercice physique, Cardiopathie coronaire, Association, Age mûr, Grande Bretagne, Royaume Uni, Europe, Adulte, Homme, Etat nutritionnel, Trouble nutrition, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Obesity, Body weight, Fluctuations, Predictive factor, Physical exercise, Coronary heart disease, Association, Middle age, Great Britain, United Kingdom, Europe, Adult, Human, Nutritional status, Nutrition disorder, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0108375
Code Inist : 002B30A01A2. Création : 22/06/1998.