Data from a representative sample of U.S. adults were used to assess the extent of familial alcoholism, to examine its association with the odds of DSM-IV lifetime alcohol dependence, major depression, and their comorbid occurrence, and to determine whether the magnitude of this association was different for men and women.
Self-report data from a sample of 42,862 U.S. adults (25,043 women) 18 years of age and over were analyzed by means of multiple logistic regression models that predicted the odds of various combinations of DSM-IV alcohol dependence and major depression.
After adjusting for potential confounders through multiple logistic regression, family history saturation was associated with increased odds of dependence only, depression only, and all primary-secondary-concurrent combinations of these two disorders.
The estimated effects were greatest for comorbid dependence and depression, next highest for dependence only and lowest for depression only.
Differences in odds ratios among these groups increased with degree of family history saturation but were statistically significant at all levels of saturation.
The effects of family history were greater for men than women for the outcome of primary depression followed by secondary dependence, but only at the higher levels of saturation. (...)
Mots-clés Pascal : Dépendance, Boisson alcoolisée, Alcoolisme, Etat dépressif, Association morbide, Histoire familiale, Sexe, Epidémiologie, Santé mentale, Homme, Trouble humeur
Mots-clés Pascal anglais : Dependence, Alcoholic beverage, Alcoholism, Depression, Concomitant disease, Family story, Sex, Epidemiology, Mental health, Human, Mood disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0107449
Code Inist : 002B18C05B. Création : 22/06/1998.