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  1. Geographic variation in Breast cancer incidence rates in a cohort of U.S. women.

    Article - En anglais


    Breast cancer mortality and incidence rates vary by geographic region in the United States.

    Previous analytic studies have measured mortality, not incidence, and have used regional prevalences to control for geographic variation in risk factors rather than adjusting for risk factors measured at the level of the individual.

    We prospectively evaluated regional variation in breast cancer incidence rates in the Nurses'Health Study and assessed the influence of breast cancer risk factors measured at the individual level.


    The Nurses'Health Study cohort was established in 1976 when 121700 female nurses aged 30-55 years living in 11 U.S. states were enrolled.

    These states represent all four regions of the continental United States.

    We identified 3603 incident cases of invasive breast cancer through 1992 (1794565 person-years of follow-up).

    We calculated relative risks (RRs) adjusted for age and for age and established risk factors (i.e., multivariate-adjusted analysis), comparing California, the Northeast, and the Midwest with the South.


    For premenopausal women, there was little evidence of regional variation in breast cancer incidence rates, either in age-adjusted or in multivariate-adjusted analyses.

    For postmenopausal women in California, age-adjusted risk was modestly elevated (RR=1.24 ; 95% confidence interval. (...)

    Mots-clés Pascal : Etude cohorte, Homme, Femelle, Variation géographique, Carcinome, Glande mammaire, Incidence, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Tumeur maligne, Glande mammaire pathologie

    Mots-clés Pascal anglais : Cohort study, Human, Female, Geographical variation, Carcinoma, Mammary gland, Incidence, Epidemiology, United States, North America, America, Malignant tumor, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0104302

    Code Inist : 002B20E02. Création : 22/06/1998.