To examine the change in uptake of interventions to reduce transmission of HIV from mothers to infants from January 1994 to July 1997.
Review of mother-infant pairs who presented for infant diagnosis of HIV infection.
Central London hospital with facilities for diagnosis of infant HIV infection.
57 consecutive mother-infant pairs, mainly from central London but also referred from surrounding hospitals.
Data were collected on mother's country of origin ; CD4 count at delivery ; plasma HIV RNA copies/ml ; mode of delivery ; antiretroviral therapy ; infant feeding ; and HIV infection in infants.
HIV infection of infants.
The vertical transmission rate was 12% (7 pairs ; 95% confidence interval 3% to 22%). All mothers chose not to breast feed.
The caesarean section rate was 53% (30/57).
Antiretroviral therapy was taken by 68.5% (39/57) of mother-infant pairs.
With antiretroviral therapy or caesarean section, or both, transmission occurred in 6% (0% to l3%) of pairs (3/50).
During the 24 months of 1994 and 1995,21% (4/19) of infants were infected with HIV ; 7.9% (3/38) were infected over the 19 months January 1996 to July 1997.
The caesarean section rate did not change over these periods.
Use of antiretroviral therapy increased from 31.5% (6/19) to 86.8% (33/38) (P<0.0001). (...)
Mots-clés Pascal : SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Prévention, Contamination, Transmission mère enfant, Chimiothérapie, Antiviral, Césarienne, Etude statistique, Homme, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Prevention, Contamination, Mother to child transmission, Chemotherapy, Antiviral, Cesarean section, Statistical study, Human, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0103883
Code Inist : 002B30A01C. Création : 22/06/1998.