- To review the scientific literature on the effectiveness of rapid opioid detoxification (RD) (opioid withdrawal precipitated by naloxone hydrochloride or naltrexone) and ultrarapid opioid detoxification (URD) (opioid withdrawal precipitated by naloxone or naltrexone under anesthesia or heavy sedation) techniques.
- The MEDLINE database was searched from 1966 through 1997 using the indexing terms naloxone, naltrexone, substance dependence, and substance withdrawal syndrome.
Additional data sources included bibliographies of papers identified on MEDLINE and bibliographies in textbooks on substance abuse.
- Inclusion criteria were studies of RD or URD, pharmacologic protocols specified, and clinical outcomes specified and reported.
Exclusion criteria were unpublished data, data not in peer-reviewed journals, abstract-only publications, and review articles.
- The methodologic characteristics of studies were extracted by the authors and summarized according to key components of research design concerning subject characteristics, therapy allocation, and outcomes assessed.
- A qualitative analysis was performed on the 12 studies of RD and the 9 studies of URD identified in our search.
The RD studies enrolled 641 subjects (range for individual studies, 1-162) : 7 were inpatient studies, and the protocols varied considerably, as did the outcomes assessed. (...)
Mots-clés Pascal : Toxicomanie, Opiacés, Pharmacocinétique, Naloxone, Etude comparative, Article synthèse, Détoxication, Méthodologie, Homme, Randomisation, Morphinane dérivé, Pharmacovigilance, Antagoniste analgésique narcotique
Mots-clés Pascal anglais : Drug addiction, Opiates, Pharmacokinetics, Naloxone, Comparative study, Review, Detoxication, Methodology, Human, Randomization, Morphinan derivatives, Pharmacovigilance, Narcotic antagonist
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0103138
Code Inist : 002B03D. Création : 22/06/1998.