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  1. Long-term survival of people with unprovoked seizures : A population-based study.

    Article - En anglais

    Purpose 

    Few population-based studies of long-term survival in people with seizures or epilepsy have been made.

    Methods 

    Between January 1,1960 and December 31,1964, we identified 224 incidence cases of unprovoked seizures in Iceland and determined survivorship status and date of death for the cases as of January 1,1996.

    We compared survivorship with that expected based on data from age-/sex-specific life tables from the country for 1961-1990 and calculated the standardized mortality ratio (SMR).

    Results 

    By 30 years after diagnosis, there were 45 deaths among patients with unprovoked seizures as compared with an expected 28 deaths [standardized mortality ratio (SMR) 1.6 ; 95% confidence interval (CI) 1.2-2.2]. Patients with unprovoked seizures of unknown etiology did not have a significant increase in mortality overall (SMR 1.3,95% CI 0.8-1.9) or in any time interval.

    For patients with remote symptomatic unprovoked seizures, mortality was increased (SMR 2.3. 95% CI 1.4-3.5).

    This increase was attributable to excess mortality for the first 15 years after diagnosis (SMR 4.1,95% CI 2.4-6.6), and SMR was not different after that time.

    Conclusions 

    Survivorship was decreased for the population of patients with unprovoked seizures.

    The increased mortality was primarily due to excess mortality in patients with remote symptomatic seizures, occurring in the first 15 years after diagnosis.

    Overall mortality for idiopathic unprovoked seizures was not significantly increased.

    Mots-clés Pascal : Epilepsie, Convulsion, Islande, Iles Atlantiques, Survie, Long terme, Mortalité, Epidémiologie, Etude cohorte, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Trouble neurologique

    Mots-clés Pascal anglais : Epilepsy, Convulsion, Iceland, Atlantic Ocean Islands, Survival, Long term, Mortality, Epidemiology, Cohort study, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Neurological disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0103073

    Code Inist : 002B17A03. Création : 22/06/1998.