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  1. Survival prognostic factors and markers of morbidity in Spanish patients with systemic sclerosis.

    Article - En anglais

    Objective

    -To identify survival prognostic factors and markers of morbidity among patients with systemic sclerosis (SSc).

    Patients and Methods--The study included 72 patients diagnosed with SSc.

    According to the extent of skin involvement, three groups of patients were established :

    • group 1, without sclerosis and with sclerosis of fingers and neck ;

    • group 2, with sclerosis of face and distal to elbows and knees ;

    • group 3, with generalised sclerosis including the trunk.

    All patients were included in a study protocol to determine visceral involvement.

    Cumulative survival after first symptom has been estimated according to the Kaplan-Meier method.

    The association between a hypothetical prognostic factor and cumulative survival after first symptom was assessed by log rank test.

    The association between a hypothetical risk factor and the prevalence of severe morbity was assessed by the odds ratio.

    Multiple logistic regression models were used to identify the main predictors of severe morbidity.

    Results

    --Survival was estimated to be 85% 10 years after first SSc symptom.

    Survival was higher among SSc patients with skin involvement distal to elbows and knees than among the rest of patients ; a forced vital capacity (FVC) on spirometry lower than 70% of expected value was associated with a shorter survival, even after adjustment for diffuse SSc.

    Skin involvement proximal to elbows or knees was associated with a higher prevalence of severe morbidity (OR=46.57 ; p<0.001). (...)

    Mots-clés Pascal : Sclérodermie, Homme, Espagnol, Epidémiologie, Symptomatologie, Peau, Poumon, Facteur prédictif, Morbidité, Pronostic, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie

    Mots-clés Pascal anglais : Scleroderma, Human, Spanish, Epidemiology, Symptomatology, Skin, Lung, Predictive factor, Morbidity, Prognosis, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0102799

    Code Inist : 002B07. Création : 22/06/1998.