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  1. Serum levels of prostate-specific antigen among Japanese-American and native Japanese men.

    Article - En anglais

    Background 

    Fourfold to sixfold higher prostate cancer rates in Japanese-American men in the United States compared with Japanese men in Japan have been cited to support a role for environmental risk factors in the etiology of the disease.

    To examine the hypothesis that part or all of the elevated prostate cancer rates in Japanese-American men may reflect more intensive prostate cancer screening in the United States than in Japan, we compared prostate-specific antigen (PSA) levels in community-based samples of serum from men without prostate cancer.

    Methods 

    Japanese-American men aged 40-85 years and native Japanese men aged 40-89 years with no history of prostate cancer provided sera, respectively, in the United States from March 1990 through March 1992 (n=237) or in Japan from January 1992 through December 1993 (n=3522).

    Age-specific PSA levels were used to estimate the prevalences of undetected prostate cancer in the two populations.

    Results 

    Age-specific mean PSA levels were significantly lower in Japanese-Americans than in native Japanese (two-sided P<. 001).

    The prevalence of an elevated PSA level increased with age in both populations and exceeded 5% among men aged 60 years or more.

    Combined with data on prevalence of detected prostate cancer in the two populations, our data suggest that some 10.0% of Japanese-Americans aged 75 years have prostate cancer, with 31% of that fraction remaining undiagnosed. (...)

    Mots-clés Pascal : Tumeur maligne, Prostate, Prévalence, Epidémiologie, Japon, Asie, Etats Unis, Amérique du Nord, Amérique, Japonais, Antigène spécifique prostate, Marqueur tumoral, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie

    Mots-clés Pascal anglais : Malignant tumor, Prostate, Prevalence, Epidemiology, Japan, Asia, United States, North America, America, Japanese, Prostate specific antigen, Tumoral marker, Human, Male genital diseases, Urinary system disease, Prostate disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0100710

    Code Inist : 002B14D02. Création : 22/06/1998.