Fourfold to sixfold higher prostate cancer rates in Japanese-American men in the United States compared with Japanese men in Japan have been cited to support a role for environmental risk factors in the etiology of the disease.
To examine the hypothesis that part or all of the elevated prostate cancer rates in Japanese-American men may reflect more intensive prostate cancer screening in the United States than in Japan, we compared prostate-specific antigen (PSA) levels in community-based samples of serum from men without prostate cancer.
Japanese-American men aged 40-85 years and native Japanese men aged 40-89 years with no history of prostate cancer provided sera, respectively, in the United States from March 1990 through March 1992 (n=237) or in Japan from January 1992 through December 1993 (n=3522).
Age-specific PSA levels were used to estimate the prevalences of undetected prostate cancer in the two populations.
Age-specific mean PSA levels were significantly lower in Japanese-Americans than in native Japanese (two-sided P<. 001).
The prevalence of an elevated PSA level increased with age in both populations and exceeded 5% among men aged 60 years or more.
Combined with data on prevalence of detected prostate cancer in the two populations, our data suggest that some 10.0% of Japanese-Americans aged 75 years have prostate cancer, with 31% of that fraction remaining undiagnosed. (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Prévalence, Epidémiologie, Japon, Asie, Etats Unis, Amérique du Nord, Amérique, Japonais, Antigène spécifique prostate, Marqueur tumoral, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Prevalence, Epidemiology, Japan, Asia, United States, North America, America, Japanese, Prostate specific antigen, Tumoral marker, Human, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0100710
Code Inist : 002B14D02. Création : 22/06/1998.