Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers.
The consumption of alcoholic beverages is a strong risk factor for cancers of the oral cavity and pharynx (oral cancers).
Alcohol dehydrogenase type 3 (ADH3) metabolizes ethanol to acetaldehyde, a carcinogen.
We evaluated whether individuals homozygous for the fast-metabolizing ADH31 allele (ADH31-1) have a greater risk of developing oral cancer in the presence of alcoholic beverage consumption than those with the slow-metabolizing ADH32 allele (ADH31-2 and ADH32-2).
As part of a population-based study of oral cancer conducted in Puerto Rico, the ADH3 genotypes of 137 patients with histologically confirmed oral cancer and of 146 control subjects (i.e., individuals with no history of oral cancer) were determined by molecular genetic analysis of oral epithelial cell samples.
Risks were estimated by use of multiple logistic regression analyses.
Compared with nondrinkers with the ADH31-1 genotype, consumers of at least 57 alcoholic drinks per week with the ADH31-1, ADH2, and ADH32-2 genotypes had 40.1-fold (95% confidence interval [CI]=5.4-296.0), 7.0-fold (95% CI=1.4-35.0), and 4.4-fold (95% CI=0.6-33.0) increased risks of oral cancer, respectively ; the risk associated with the ADH31-1 genotype, compared with the ADH31-2 and ADH32-2 genotypes combined, was 5.3 (95% CI=1.0-28.8) among such drinkers.
Considering all levels of alcohol consumption, the risk of oral cancer per additional alcoholic drink per week increased 3.6%. (...)
Mots-clés Pascal : Tumeur maligne, Pharynx, Cavité buccale, Facteur risque, Ethanol, Consommation, Alcohol dehydrogenase, Oxidoreductases, Enzyme, Génotype, Polymorphisme, Variabilité génétique, Epidémiologie, Etude cas témoin, Porto Rico, Antilles, Amérique Centrale, Amérique, Homme, ORL pathologie, Pharynx pathologie, Cavité buccale pathologie, Stomatologie
Mots-clés Pascal anglais : Malignant tumor, Pharynx, Oral cavity, Risk factor, Ethanol, Consumption, Alcohol dehydrogenase, Oxidoreductases, Enzyme, Genotype, Polymorphism, Genetic variability, Epidemiology, Case control study, Puerto Rico, West Indies, Central America, America, Human, ENT disease, Pharynx disease, Oral cavity disease, Stomatology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0100708
Code Inist : 002B10B01. Création : 22/06/1998.