Second primary cancers related to smoking and treatment of small-cell lung cancer.
An increased risk of second primary cancers has been reported in patients who survive small-cell carcinoma of the lung.
The treatment's contribution to the development of second cancers is difficult to assess, in part because the number of long-term survivors seen at any one institution is small.
We designed a multi-institution study to investigate the risk among survivors of developing second primary cancers other than small-cell lung carcinoma.
Demographic, smoking, and treatment information were obtained from the medical records of 611 patients who had been cancer free for more than 2 years after therapy for histologically proven small-cell lung cancer, and person-years of follow-up were cumulated.
Population-based rates of cancer incidence and mortality were used to estimate the expected number of cancers or deaths.
The actuarial risk of second cancers was estimated by the Kaplan-Meier method.
Relative to the general population, the risk of all second cancers among these patients (mostly non-small-cell cancers of the lung) was increased 3.5-fold.
Second lung cancer risk was increased 13-fold among those who received chest irradiation in comparison to a sevenfold increase among nonirradiated patients.
It was higher in those who continued smoking, with evidence of an interaction between chest irradiation and continued smoking (relative risk=21). (...)
Mots-clés Pascal : Carcinome petite cellule, Bronchopulmonaire, Facteur risque, Second cancer, Tabagisme, Chimiothérapie, Anticancéreux, Agent alkylant, Traitement, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Tumeur maligne
Mots-clés Pascal anglais : Small cell carcinoma, Bronchopulmonary, Risk factor, Second cancer, Tobacco smoking, Chemotherapy, Antineoplastic agent, Alkylating agent, Treatment, Epidemiology, United States, North America, America, Human, Respiratory disease, Lung disease, Bronchus disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0100701
Code Inist : 002B11A. Création : 22/06/1998.