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  1. Hepatocellular carcinoma : From gene to public health.

    Article - En anglais

    Liver diseases associated with chronic hepatitis B virus (HBV) infection, including hepatocellular carcinoma, account for more than 1 million deaths annually worldwide.

    In addition to HBV infection, other risk factors are involved in the etiology of hepatocellular carcinoma and, among these, dietary exposure to the carcinogenic aflatoxins is of particular importance in certain regions of southeast Asia and sub-Saharan Africa.

    The relative contributions of these two risk factors and the mechanism of the interaction between them in the pathogenesis of hepatocellular carcinoma are still poorly understood.

    The recently developed individual biochemical and molecular markers of aflatoxin exposure, i.e., aflatoxin-albumin adducts in blood and a specific GC to TA transversion mutation in codon 249 of the p53 gene (249ser p53 mutation) in hepatocellular carcinomas, permit a better quantitative estimation of aflatoxin exposure in different populations of the world. (...)

    Mots-clés Pascal : Carcinome hépatocellulaire, Gène suppresseur tumeur, Gène TP53, Aflatoxine, Carcinogène, Carcinogenèse, Marqueur biologique, Pathogénie, Prévention, Hépatite virale B, Virose, Infection, Chronique, Article synthèse, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Hepatocellular carcinoma, Tumor suppressor gene, TP53 Gene, Aflatoxin, Carcinogen, Carcinogenesis, Biological marker, Pathogenesis, Prevention, Viral hepatitis B, Viral disease, Infection, Chronic, Review, Human, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0100696

    Code Inist : 002B13C01. Création : 22/06/1998.