To test the hypothesis of an association between neonatal intramuscular vitamin K and childhood leukaemia and other cancers.
Population based case-control study with data ed from hospital records.
Children aged 0-14 years resident in Scotland from 1991-4 and diagnosed with leukaemia (150), lymphomas (46), central nervous system tumours (79), a range of other solid tumours (142), and a subset of acute lymphoblastic leukaemia (129).
Controls were 777 children matched for age and sex, providing 417 matched sets (360 triplets and 57 pairs) for analysis.
Odds ratios for the risk of childhood leukaemia and cancer and intramuscular vitamin K versus a combined group of oral doses, none, and no record.
Results are given for information recorded in medical notes and data supplemented by hospital policy.
Odds ratios based on medical record ions showed no significant positive association for leukaemias (odds ratio 1.30 ; 95% confidence interval 0.83 to 2.03), acute lymphoblastic leukaemia (1.21 ; 0.74 to 1.97), lymphomas (1.06 ; 0.46 to 2.42), central nervous system tumours (0.74 ; 0.40 to 1.34), and other solid tumours (0.59 ; 0.37 to 0.96).
There was no association with acute lymphoblastic leukaemia in children aged 1 to 6 years.
Imputation of exposure from hospital policy gave similar results. (...)
Mots-clés Pascal : Leucémie, Lymphome, Tumeur maligne, Incidence, Relation incertitude, Chimiothérapie, Antifibrinolytique, Vitamine K, Voie intramusculaire, Etude cas témoin, Enfant, Homme, Ecosse, Grande Bretagne, Royaume Uni, Europe, Hémopathie maligne, Pharmacovigilance
Mots-clés Pascal anglais : Leukemia, Lymphoma, Malignant tumor, Incidence, Uncertainty relation, Chemotherapy, Antifibrinolytic, Vitamin K, Intramuscular administration, Case control study, Child, Human, Scotland, Great Britain, United Kingdom, Europe, Malignant hemopathy, Pharmacovigilance
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0095480
Code Inist : 002B02U10. Création : 14/05/1998.