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  1. The FMR1 and FMR2 mutations are not common etiologies of academic difficulty among school-age children.

    Article - En anglais

    The prevalence of the fragile X mental retardation (FMR) 1 and FMR2 full mutations (fM) was examined among 1014 school-age children with academic difficulties but without mental retardation.

    Both Southern blot and polymerase chain reaction analyses for FMR1 and FMR2 were performed on samples obtained from these children.

    No fM genes were found, and one FMR1 premutation was identified.

    The distribution of allele sizes for both genes was comparable to those reported for other clinical and normal population samples.

    These results suggest that neither the FMR1 nor the FMR2 mutation is a common etiology of academic failure among school-age children without mental retardation and that the prevalence of the FMR1 premutation is no more frequent in children with academic failure than it is in the general population.

    Mots-clés Pascal : X fragile syndrome, Echec scolaire, Etiologie, Mutation, Etude comparative, Prévalence, Epidémiologie, Age scolaire, Enfant, Homme, Préadolescent, Adolescent, Fragilité chromosomique

    Mots-clés Pascal anglais : Fragile X syndrome, School failure, Etiology, Mutation, Comparative study, Prevalence, Epidemiology, School age, Child, Human, Preadolescent, Adolescent, Chromosome fragility

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0094768

    Code Inist : 002A26K04. Création : 14/05/1998.