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  1. What other regimens are under investigation to treat Helicobacter pylori infection ?

    Article, Communication - En anglais

    American Digestive Health Foundation International Update Conference on Helicobacter pylori. McLean, VA, USA, 1997/02/13.

    The most common infection in the world, Helicobacter pylori infection, is very specific, and present experience in treating infectious diseases is not applicable in general for this infection.

    Animal models (e.g., mouse and ferret) are thus far inadequate as reliable screening models.

    Old-fashioned trial-and-error treatment of infected humans is still the screening model and the gold standard in the evaluation of regimens aimed at eradication of H. pylori.

    A variety of studies on treatment of H. pylori infection have been performed with varying results.

    This pooled analysis of the following therapeutic combinations : proton pump inhibitor (PPI) plus two antibiotics or antimicrobials, quadruple therapies, and nonantibiotic regimens is an attempt to make a fair comparison of tested therapeutic strategies aimed at eradicating H. pylori.

    Data from treatment groups including specified drug combinations are pooled, regardless of dose or duration.

    Search methods are :

    MEDUNE 1984-1996, Digestive Disease Week 1988-1996, United European Gastroenterolgy Week 1992-1996, European Helicobacter pylori Study Group 1988-1996, Asia Pacific Congress 1996, H. pylon Intemational Workshop Hong Kong 1996, and miscellaneous.

    Eradication rates (efficacy) are presented as intention-to-treat data (i.e., worst-case analysis).

    Separate subanalyses with regard to study quality, dose, and duration are performed for some groups. (...)

    Mots-clés Pascal : Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Chimiothérapie, Association médicamenteuse, Protocole thérapeutique, Evaluation performance, Revue bibliographique, Homme, Appareil digestif pathologie, Estomac pathologie

    Mots-clés Pascal anglais : Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Chemotherapy, Drug combination, Therapeutic protocol, Performance evaluation, Bibliographic review, Human, Digestive diseases, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0093924

    Code Inist : 002B02H. Création : 14/05/1998.