logo BDSP

Base documentaire

  1. Effect of nationwide vaccination of 3-month-old infants in The Netherlands with conjugate Haemophilus influenzae type b vaccine : High efficacy and lack of herd immunity.

    Article - En anglais


    The effect of nationwide vaccination in The Netherlands with conjugate Haemophilus influenzae type b vaccine on the incidence of H. influenzae meningitis was as sessed in the first 3 years after the introduction of vaccination to the birth cohort at 3 months of age.

    Study design 

    Children in The Netherlands born after April 1,1993, were vaccinate at the age of 3,4,5, and 11 months.

    Children older than 3 months at the inception of the H. influenzae type b vaccination program were not immunized.

    The number of cases among the vaccine cohort was compared with the number in a historical control group of children born in the period April 1,1990, and April 1,1993.


    The total number of patients with meningitis caused by H. influenzae type b reached a low, but constant level, that was expected for absence of herd immunity.

    Among children in the vaccine era group 22 cases occurred, whereas among the histori cal control group (prevaccine era) 342 cases were found.

    In the vaccine era cohort, 2 patients with H. influenzae type b meningitis had been vaccinated three times, 13 received one or no vaccine dose because of their age, and 7 were not vaccinated for religious or logistic reasons.

    The number of cases among nonvaccinated children older than 3 years and the number of H. influenzae meningitis cases caused by strains other than type b did not change.


    Conjugate H. influenzae type b vaccine prevents H. (...)

    Mots-clés Pascal : Haemophilus influenzae, Pasteurellaceae, Bactérie, Vaccination, Traitement, Prévention, Immunothérapie, Nourrisson, Homme, Epidémiologie, Incidence, Infection, Méningite, Politique sanitaire, Efficacité traitement, Bactériose, Système nerveux pathologie, Système nerveux central pathologie

    Mots-clés Pascal anglais : Haemophilus influenzae, Pasteurellaceae, Bacteria, Vaccination, Treatment, Prevention, Immunotherapy, Infant, Human, Epidemiology, Incidence, Infection, Meningitis, Health policy, Treatment efficiency, Bacteriosis, Nervous system diseases, Central nervous system disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0090822

    Code Inist : 002B05B02I. Création : 14/05/1998.