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  1. Incidence of premature birth and neonatal respiratory disease in infants of HIV-positive mothers.

    Article - En anglais


    We sought to determine the prematurity rate in infants of HIV-positive mothers and to characterize the incidence and severity of neonatal respiratory disease'in this population.

    Study design 

    From 1990 to 1994,600 live-born infants of HIV-infected mothers were enrolled prenatally (73%) or postnatally (27%) from five U.S. centers.

    Logistic regression was used to determine the association of HIV status in the infant with prematurity (¾37 weeks), low birth weight (¾2.5 kg), and very low birth weight (¾1.5 kg) rates.

    The incidence of respiratory distress syndrome (RDS), bronchopulmonary dysplasia, meconium aspiration syndrome, and neonatal pneumonia was compared with anticipated rates for gestational age and birth weight.


    Very high rates of prematurity (19%), low birth weight (18.3%), and very low birth weight (3.3%) were found in the infants of HIV-positive mothers ; and HIV infection in the infant was associated with younger gestational age.

    The overall incidence of RDS was 3% (17/600), which coincided with the anticipated rate, after adjusting for prematurity and birth weight.

    Only five infants (all ¾ 1.5 kg) had bronchopulmonary dysplasia, and none required assisted ventilation beyond 14 days.

    Three term infants had mild meconium aspiration syndrome, and there were no cases of documented neonatal pneumonia. (...)

    Mots-clés Pascal : Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Séropositivité, Mère, Etude impact, Gestation, Nouveau né, Homme, Dysplasie bronchopulmonaire, Prématurité, Détresse respiratoire, Epidémiologie, Incidence, Prématuré, Gestation pathologie, Virose, Infection, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Nouveau né pathologie

    Mots-clés Pascal anglais : Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Seropositivity, Mother, Impact study, Pregnancy, Newborn, Human, Bronchopulmonary dysplasia, Prematurity, Respiratory distress, Epidemiology, Incidence, Premature, Pregnancy disorders, Viral disease, Infection, Respiratory disease, Lung disease, Bronchus disease, Newborn diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0090820

    Code Inist : 002B05C02D. Création : 14/05/1998.