We conducted a meta-analysis of the published randomized clinical trials of vitamin E prophylaxis designed to reduce retinopathy of prematurity (ROP) to determine whether increased serum concentrations of vitamin E reduced the incidence of severe, threshold (Stage 3+) ROP in the very low birth weight (VLBW) infant subset.
Among the six trials considered eligible for analyses, the incidence for all stages of ROP and for Stage 3+ROP was computed for all randomly assigned infants (intention-to-treat analysis) and for those infants completing the trials.
Odds ratios (ORs) and pooled estimates for event rate reductions (and the respective 95% confidence intervals [CIs]) were calculated for these outcome end points.
There were 704 VLBW infants in the vitamin E prophylaxis groups and 714 in control groups ; 536 (76.1%) infants in the vitamin E and 551 (77.2%) in the control groups completed the trials.
In all trials the mean serum vitamin E concentrations were within or above the physiologic range in the vitamin-treated groups and at or below the physiologic ranges in the control groups.
The overall incidence of any stage ROP was similar between the groups : 39.8% in the vitamin E group and 43.5% in the control group.
The overall incidence for Stage 3+ROP was lower in the vitamin E-treated groups than in the control group (2.4% in vitamin E vs 5.3% in control).
The pooled OR for developing Stage 3+ROP with vitamin E prophylaxis was 0. (...)
Mots-clés Pascal : Fibroplasie rétrolentale, Nouveau né, Homme, Prématurité, Traitement, Prévention, Chimiothérapie, alpha-Tocophérol, Complément alimentaire, Efficacité traitement, Exploration, Concentration, Sérum, Epidémiologie, Incidence, Essai clinique, Revue bibliographique, Prématuré, Oeil pathologie, Rétinopathie, Nouveau né pathologie
Mots-clés Pascal anglais : Retrolental fibroplasia, Newborn, Human, Prematurity, Treatment, Prevention, Chemotherapy, alpha-Tocopherol, Food supplement, Treatment efficiency, Exploration, Concentration, Serum, Epidemiology, Incidence, Clinical trial, Bibliographic review, Premature, Eye disease, Retinopathy, Newborn diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0090819
Code Inist : 002B26B. Création : 14/05/1998.