Helicobacter pylori injection is mainly acquired in childhood, and studies on the epidemiology of this infection depend on the availability of a noninvasive diagnostic test for use in children.
The aim of this study was to determine whether the carbon 13-labeled urea breath test (UBT) can be used in children by evaluating : (1) its sensitivity and specificity compared with either culture or both rapid urease test and histologic examination, (2) whether a test meal or a prolonged fast is required, (3) the usefulness after treatment for H. pylori.
Eighty-eight children (mean age, 10.6 ± 4.19 years) who were undergoing upper endoscopy were studied while fasting, not fasting, and after treatment.
Children were given 50 mg of 13C-urea if they weighed less than 50 kg or 75 mg of 13C-urea if they weighed more than 50 kg with 50 mg of a glucose polymer solution in 7.5 ml of water.
Breath samples were collected at baseline and at 15,30,45, and 60 minutes.
In 63 fasting children the UBT was 100% sensitive and 97.6% specific at 30 minutes with a cutoff value of 3.5 6 13CO2 per mil.
Nonfasting tests in 23 children, performed between I and 2 hours after their usual meal, were 100% sensitive and 91.6% specific.
In 13 children fed directly before the UBT, the sensitivity of the test was reduced to 50%. Thirty minutes was the optimal sampling time. (...)
Mots-clés Pascal : Infection, Gastrointestinal, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Epidémiologie, Exploration, Diagnostic, Test respiratoire, Urée, Exploration radioisotopique, Enfant, Homme, Méthodologie, Sensibilité, Spécificité, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Bactériose
Mots-clés Pascal anglais : Infection, Gastrointestinal, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Epidemiology, Exploration, Diagnosis, Breath test, Urea, Radionuclide study, Child, Human, Methodology, Sensitivity, Specificity, Digestive diseases, Gastric disease, Intestinal disease, Bacteriosis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0090814
Code Inist : 002B24B05. Création : 14/05/1998.