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  1. Carbon 13-labeled urea breath test for the diagnosis of Helicobacter pylori infection in children.

    Article - En anglais

    Helicobacter pylori injection is mainly acquired in childhood, and studies on the epidemiology of this infection depend on the availability of a noninvasive diagnostic test for use in children.

    The aim of this study was to determine whether the carbon 13-labeled urea breath test (UBT) can be used in children by evaluating : (1) its sensitivity and specificity compared with either culture or both rapid urease test and histologic examination, (2) whether a test meal or a prolonged fast is required, (3) the usefulness after treatment for H. pylori.

    Eighty-eight children (mean age, 10.6 ± 4.19 years) who were undergoing upper endoscopy were studied while fasting, not fasting, and after treatment.

    Children were given 50 mg of 13C-urea if they weighed less than 50 kg or 75 mg of 13C-urea if they weighed more than 50 kg with 50 mg of a glucose polymer solution in 7.5 ml of water.

    Breath samples were collected at baseline and at 15,30,45, and 60 minutes.

    In 63 fasting children the UBT was 100% sensitive and 97.6% specific at 30 minutes with a cutoff value of 3.5 6 13CO2 per mil.

    Nonfasting tests in 23 children, performed between I and 2 hours after their usual meal, were 100% sensitive and 91.6% specific.

    In 13 children fed directly before the UBT, the sensitivity of the test was reduced to 50%. Thirty minutes was the optimal sampling time. (...)

    Mots-clés Pascal : Infection, Gastrointestinal, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Epidémiologie, Exploration, Diagnostic, Test respiratoire, Urée, Exploration radioisotopique, Enfant, Homme, Méthodologie, Sensibilité, Spécificité, Appareil digestif pathologie, Estomac pathologie, Intestin pathologie, Bactériose

    Mots-clés Pascal anglais : Infection, Gastrointestinal, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Epidemiology, Exploration, Diagnosis, Breath test, Urea, Radionuclide study, Child, Human, Methodology, Sensitivity, Specificity, Digestive diseases, Gastric disease, Intestinal disease, Bacteriosis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0090814

    Code Inist : 002B24B05. Création : 14/05/1998.