To determine the prevalence and routes of transmission of hepatitis C virus (HCV) infection in Hafizabad, Pakistan, we collected sera in 1993 from a geographically based random sample of residents, and in 1994 identified 15 HCV-infected individuals (cases) and 67 age and sex matched uninfected individuals (controls).
Initially we approached 504 households, and collected serum from a randomly selected household member in 309 (64%). Twenty persons (65%) had anti-HCV antibody ; 31% percent had hepatitis B core antibodies, and 4.3% had hepatitis B surface antigen.
In the case-control study, persons who received more therapeutic injections (categorized as averaging 1,2-4,5-9 or>10 injections per year in the previous 10 years) were more likely to be infected with HCV (odds ratio 0,1.5,2.5 and 6.9 respectively, P=0.008) compared to persons averaging 0 injections per year.
Efforts to limit therapeutic injections to only those that are medically indicated and that use sterile equipment are essential in order to prevent transmission of HCV.
Mots-clés Pascal : Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Prévalence, Etude cas témoin, Traitement, Voie intraveineuse, Prévention, Transmission, Hépatite virale C, Virose, Infection, Homme, Epidémiologie, Appareil digestif pathologie, Foie pathologie, Pakistan, Asie
Mots-clés Pascal anglais : Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Prevalence, Case control study, Treatment, Intravenous administration, Prevention, Transmission, Viral hepatitis C, Viral disease, Infection, Human, Epidemiology, Digestive diseases, Hepatic disease, Pakistan, Asia
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0090530
Code Inist : 002B30A03B. Création : 14/05/1998.