Applicability of aspecific noninvasive methods for biomonitoring of occupational exposure to deltamethrin : Preliminary study using an animal model.
Deltamethrin (CAS registry No. 52918-63-5), a synthetic dibromo-pyrethroid insecticide is highly effective against a broad spectrum of insects, and is widely used on crops and in public health programs.
Data on the genotoxicity and carcinogenicity of deltamethrin are rather controversial, depending on the genetic system or the assay used.
The aim of the present study was to analyze previously demonstrated metabolic changes using aspecific noninvasive methods in rats which are potentially applicable for monitoring occupational exposure.
Since human exposure to pesticides occurs not only to active principles but to all chemicals present in a commercial formulation, we tested both the pure compound and a deltamethrin-based commercial formulation.
Groups of rats were treated, i.p., consecutively for 7 days.
The daily doses tested were 5 and 10 mg/kg body weight for pure deltamethrin, corresponding to volumes of 178.57 and 377.14 mul/kg body weight for the commercial formulation (containing 2.8% deltamethrin).
Urine was analyzed for mutagenic metabolites, thioethers, and D-glucaric acid content.
Faeces extracts were tested for mutagenicity.
Results show that DGA urinary excretion values did not mirror the phase I enzyme induction capability of the insecticide.
Results obtained for urinary thioethers do not agree completely with those obtained on the influence of deltamethrin on glutathione S-transferase activity in rat liver. (...)
Mots-clés Pascal : Pesticide, Insecticide, Toxicité, Exposition professionnelle, Médecine travail, Surveillance biologique, Rat, Rodentia, Mammalia, Vertebrata, Animal, Méthode étude, Méthode non invasive, Liquide biologique, Urine, Mutagène, Test mutagénicité, Pyréthrinoïde, Deltamethrin
Mots-clés Pascal anglais : Pesticides, Insecticide, Toxicity, Occupational exposure, Occupational medicine, Biological monitoring, Rat, Rodentia, Mammalia, Vertebrata, Animal, Investigation method, Non invasive method, Biological fluid, Urine, Mutagen, Mutagenicity testing, Pyrethroids, Deltamethrin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0090142
Code Inist : 002B03G. Création : 14/05/1998.