A method was developed for the biological monitoring of the fungicide epoxiconazol (Opus ; BASF).
Comparison of the urine levels of a hydroxylated metabolite after dermal application to the levels after oral intake revealed a dermal absorption of 1-2.5% of the dose.
In a field study with 10 applicators a dermal exposure ranging between 60 and 10,000 mug/person/day was determined from the urine levels of a hydroxylated metabolite ; the contribution of the inhalation exposure was found to be negligible.
From these data an incorporation of 1 to 100 mug epoxiconazol/person/day could be derived.
The measured exposure was compared to two commonly used exposure models.
The model calculation resulted in a dermal exposure of 555 mug/person/day (German BBA model) and 2115 mug/person/day (British POEM), respectively, which is in accordance with the actually measured exposure.
Mots-clés Pascal : Pesticide, Fongicide, Toxicité, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Voie externe, Voie orale, Inhalation, Pharmacocinétique, Toxicocinétique, Urine, Liquide biologique, Triazole dérivé, Epoxiconazole
Mots-clés Pascal anglais : Pesticides, Fungicide, Toxicity, Occupational exposure, Occupational medicine, Human, Biological monitoring, Topical administration, Oral administration, Inhalation, Pharmacokinetics, Toxicokinetics, Urine, Biological fluid, Triazole derivatives
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0089828
Code Inist : 002B03G. Création : 14/05/1998.