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  1. Fulltext. Nationwide oral poliovirus vaccination campaign and the incidence of Guillain-Barré syndrome.

    Article - En anglais


    A retrospective analysis of the incidence of Guillain-Barré syndrome (GBS) in Finland in 1981-1986 was carried out by careful examination of medical records identified from nationwide Hospital Discharge Register data based on a mean total population of 5 million people.

    Records from 247 patients fulfilled the accepted criteria of GBS corresponding to a mean annual incidence of 0.82 per 100,000 population.

    Monthly rates showed an increased incidence of GBS in March 1985, following by a few weeks the onset of the nationwide oral poliovirus vaccine campaign and partly overlapping it.

    Analysis of the time series in depth suggested, however, that a change point in the occurrence of GBS had already taken place before the oral poliovirus vaccine campaign.

    Widespread circulation of wild-type 3 poliovirus in the population immediately preceded the oral poliovirus vaccine campaign and the peak occurrence of GBS.

    These results demonstrate a temporal association between poliovirus infection, caused by either wild virus or live attenuated vaccine, and an episode of increased occurrence of GBS, but they cannot prove the suspected cause-effect relation between GBS and oral poliovirus vaccine administration.

    Mots-clés Pascal : Polyradiculonévrite Guillain Barré, Epidémiologie, Incidence, Rétrospective, Campagne de masse, Vaccination, Prévention, Poliovirus, Enterovirus, Picornaviridae, Virus, Voie orale, Homme, Finlande, Europe, Système nerveux pathologie, Nerf périphérique pathologie, Maladie inflammatoire

    Mots-clés Pascal anglais : Guillain Barré syndrome, Epidemiology, Incidence, Retrospective, Mass campaign, Vaccination, Prevention, Poliovirus, Enterovirus, Picornaviridae, Virus, Oral administration, Human, Finland, Europe, Nervous system diseases, Peripheral nerve disease, Inflammatory disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0081777

    Code Inist : 002B17F. Création : 14/05/1998.