A retrospective analysis of the incidence of Guillain-Barré syndrome (GBS) in Finland in 1981-1986 was carried out by careful examination of medical records identified from nationwide Hospital Discharge Register data based on a mean total population of 5 million people.
Records from 247 patients fulfilled the accepted criteria of GBS corresponding to a mean annual incidence of 0.82 per 100,000 population.
Monthly rates showed an increased incidence of GBS in March 1985, following by a few weeks the onset of the nationwide oral poliovirus vaccine campaign and partly overlapping it.
Analysis of the time series in depth suggested, however, that a change point in the occurrence of GBS had already taken place before the oral poliovirus vaccine campaign.
Widespread circulation of wild-type 3 poliovirus in the population immediately preceded the oral poliovirus vaccine campaign and the peak occurrence of GBS.
These results demonstrate a temporal association between poliovirus infection, caused by either wild virus or live attenuated vaccine, and an episode of increased occurrence of GBS, but they cannot prove the suspected cause-effect relation between GBS and oral poliovirus vaccine administration.
Mots-clés Pascal : Polyradiculonévrite Guillain Barré, Epidémiologie, Incidence, Rétrospective, Campagne de masse, Vaccination, Prévention, Poliovirus, Enterovirus, Picornaviridae, Virus, Voie orale, Homme, Finlande, Europe, Système nerveux pathologie, Nerf périphérique pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Guillain Barré syndrome, Epidemiology, Incidence, Retrospective, Mass campaign, Vaccination, Prevention, Poliovirus, Enterovirus, Picornaviridae, Virus, Oral administration, Human, Finland, Europe, Nervous system diseases, Peripheral nerve disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0081777
Code Inist : 002B17F. Création : 14/05/1998.