A mutation in the Factor V gene (Factor V Leiden), a variant in the 5,10-methylenetetrahydrofolate reductase gene (MTHFR), and an insertion/deletion polymorphism of the angiotensin I-converting enzyme gene (ACE) may be related to abnormal blood clotting.
The authors examined the associations between these genetic traits and venous thrombosis among African Americans.
This study comprised 93 patients with venous thrombosis and 185 control subjects attending clinics at an urban, public hospital in Atlanta, Georgia, in 1995-1996.
Subjects'DNA was extracted from blood and assayed for these genetic traits.
Odds ratios were obtained from logistic regression and used as a measure of association between each genetic trait and venous thrombosis.
Factor V Leiden was unrelated to venous thrombosis, but the mutation was too rare among our Africian-American subjects to evaluate adequately its relation to venous thrombosis.
The homozygous and heterozygous genotypes for the V allele of the MTHFR gene were unrelated to venous thrombosis (odds ratio=0.9,95% confidence interval 0.5-1.8).
Subjects with the deletion/deletion ACE polymorphism experienced a moderate increase in venous thrombosis risk compared with persons with the other genotypes (odds ratio=1.5,95% confidence interval 0.9-2.6).
However, women with this ACE genotype experienced no increased risk (odds ratio=0.9,95% confidence interval 0.5-1.9), whereas men with this genotype had nearly three times the risk (odds ratio=2. (...)
Mots-clés Pascal : Facteur V Leiden, 5,10-Methylenetetrahydrofolate reductase (FADH2), Oxidoreductases, Enzyme, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Peptidases, Hydrolases, Thrombose, Veine, Homme, Noir américain, Polymorphisme, Gène, Facteur coagulation, Mutation, Epidémiologie, Facteur risque, Génétique épidémiologique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Veine pathologie, Géorgie, Etats Unis, Amérique du Nord, Amérique, Race
Mots-clés Pascal anglais : Factor V Leiden, 5,10-Methylenetetrahydrofolate reductase (FADH2), Oxidoreductases, Enzyme, Peptidyl-dipeptidase A, Peptidyl-dipeptidases, Peptidases, Hydrolases, Thrombosis, Vein, Human, Black American, Polymorphism, Gene, Coagulation factor, Mutation, Epidemiology, Risk factor, Epidemiologic genetics, Cardiovascular disease, Vascular disease, Venous disease, Georgia, United States, North America, America, Race
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0081771
Code Inist : 002B12B03. Création : 14/05/1998.