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  1. Urinary naphthols as an indicator of exposure to naphthalene.

    Article - En anglais

    Objective The relationship between exposure to naphthalene and urinary excretion of naphthols was examined.

    Methods Concentrations of naphthalene and naphthols in breathing-zone air during a workshift and 1-naphthol and 2-naphthol in urine collected after the workshift were determined for 102 male workers.

    Gas chromatography with a flame ionization detector (GC-FID) was used to determine the air concentration.

    Urine naphthols were extracted after acid hydrolysis by solid-phase extraction and separated by the GC-FID method.

    Naphthalene homologues in air and their metabolites in urine samples were identified by gas chromatography-mass spectrometry.

    Results l-Naphthol, 2-naphthol and 1,4-naphthoquinone were identified in the urine samples.

    The time-weighted average concentrations of naphthalene and naphthols in the breathing-zone air showed that the exposure level of the workers was rather low.

    The geometric mean values were as follows : 0.77 and 0.87 mg/m3 for naphthalene, 0.016 and 0.034 mg/m3 for 1-naphthol, 0.012 and 0.067 mg/m3 for 2-naphthol during tar distillation and naphthalene oil distillation, respectively.

    The corresponding urinary concentrations of I-and 2-naphthols were 693.1 and 264.4 mumol/mol and 264.4 and 297.7 mumol/mol creatinine, respectively.

    The correlation coefficients between the naphthol concentrations in urine and the breathing-zone air concentrations of naphthalene were statistically significant, varying in the range of 0.64-0. (...)

    Mots-clés Pascal : Naphtalène, Exposition professionnelle, Surveillance biologique, Homme, Urine, Métabolite, Naphtol, Marqueur biologique, Médecine travail, Teneur air ambiant

    Mots-clés Pascal anglais : Naphthalene, Occupational exposure, Biological monitoring, Human, Urine, Metabolite, Naphthol, Biological marker, Occupational medicine, Ambient air concentration

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0079133

    Code Inist : 002B03L06. Création : 14/05/1998.