Objective The relationship between exposure to naphthalene and urinary excretion of naphthols was examined.
Methods Concentrations of naphthalene and naphthols in breathing-zone air during a workshift and 1-naphthol and 2-naphthol in urine collected after the workshift were determined for 102 male workers.
Gas chromatography with a flame ionization detector (GC-FID) was used to determine the air concentration.
Urine naphthols were extracted after acid hydrolysis by solid-phase extraction and separated by the GC-FID method.
Naphthalene homologues in air and their metabolites in urine samples were identified by gas chromatography-mass spectrometry.
Results l-Naphthol, 2-naphthol and 1,4-naphthoquinone were identified in the urine samples.
The time-weighted average concentrations of naphthalene and naphthols in the breathing-zone air showed that the exposure level of the workers was rather low.
The geometric mean values were as follows : 0.77 and 0.87 mg/m3 for naphthalene, 0.016 and 0.034 mg/m3 for 1-naphthol, 0.012 and 0.067 mg/m3 for 2-naphthol during tar distillation and naphthalene oil distillation, respectively.
The corresponding urinary concentrations of I-and 2-naphthols were 693.1 and 264.4 mumol/mol and 264.4 and 297.7 mumol/mol creatinine, respectively.
The correlation coefficients between the naphthol concentrations in urine and the breathing-zone air concentrations of naphthalene were statistically significant, varying in the range of 0.64-0. (...)
Mots-clés Pascal : Naphtalène, Exposition professionnelle, Surveillance biologique, Homme, Urine, Métabolite, Naphtol, Marqueur biologique, Médecine travail, Teneur air ambiant
Mots-clés Pascal anglais : Naphthalene, Occupational exposure, Biological monitoring, Human, Urine, Metabolite, Naphthol, Biological marker, Occupational medicine, Ambient air concentration
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0079133
Code Inist : 002B03L06. Création : 14/05/1998.