Urinary naphthols as an indicator of exposure to naphthalene.
Objective The relationship between exposure to naphthalene and urinary excretion of naphthols was examined.
Methods Concentrations of naphthalene and naphthols in breathing-zone air during a workshift and 1-naphthol and 2-naphthol in urine collected after the workshift were determined for 102 male workers.
Gas chromatography with a flame ionization detector (GC-FID) was used to determine the air concentration.
Urine naphthols were extracted after acid hydrolysis by solid-phase extraction and separated by the GC-FID method.
Naphthalene homologues in air and their metabolites in urine samples were identified by gas chromatography-mass spectrometry.
Results l-Naphthol, 2-naphthol and 1,4-naphthoquinone were identified in the urine samples.
The time-weighted average concentrations of naphthalene and naphthols in the breathing-zone air showed that the exposure level of the workers was rather low.
The geometric mean values were as follows : 0.77 and 0.87 mg/m3 for naphthalene, 0.016 and 0.034 mg/m3 for 1-naphthol, 0.012 and 0.067 mg/m3 for 2-naphthol during tar distillation and naphthalene oil distillation, respectively.
The corresponding urinary concentrations of I-and 2-naphthols were 693.1 and 264.4 mumol/mol and 264.4 and 297.7 mumol/mol creatinine, respectively.
The correlation coefficients between the naphthol concentrations in urine and the breathing-zone air concentrations of naphthalene were statistically significant, varying in the range of 0.64-0. (...)
Mots-clés Pascal : Naphtalène, Exposition professionnelle, Surveillance biologique, Homme, Urine, Métabolite, Naphtol, Marqueur biologique, Médecine travail, Teneur air ambiant
Mots-clés Pascal anglais : Naphthalene, Occupational exposure, Biological monitoring, Human, Urine, Metabolite, Naphthol, Biological marker, Occupational medicine, Ambient air concentration
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0079133
Code Inist : 002B03L06. Création : 14/05/1998.