logo BDSP

Base documentaire


  1. National cancer clinical trials : Children have equal access ; Adolescents do not. Commentary.

    Article - En anglais

    Purpose

    To determine whether adolescents with cancer, who in comparison to younger patients have a higher cancer incidence and lower mortality reduction, have equal access to national cancer clinical trials.

    Methods

    The ethnic/racial distribution of 29,859 subjects<20 years of age entered onto National Cancer Institute-sponsored clinical trials between January 1,1991, and June 30,1994, was compared with the expected distribution of patients of the same age in the United States.

    Results

    The Children's Cancer Group and Pediatric Oncology Group had 29,134 (97.6%) of the total study entries among<20-year-old subjects during the 3.5 years of surveillance.

    The adult cooperative groups accounted for<3% of the clinical trials entries in the 15-19-year age range.

    When analyzed nationally by region, the underrepresentation of the older adolescent subjects was universal.

    From other analyses, the two pediatric cooperative groups were estimated to have registered>94% of the children<15 years of age who were expected to have been diagnosed to have cancer, but only 21% of the cancer patients in the 15-19-year age group.

    Conclusions

    The national pediatric cancer cooperative groups allow the majority of American children<15 years of age and their families equal opportunity to access clinical cancer trials, regardless of race or ethnicity.

    Among patients 15-19 years of age, however,>75% are not being enrolled by any cooperative group sponsored by the National Cancer Institute. (...)

    Mots-clés Pascal : Tumeur maligne, Incidence, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Essai clinique, Accessibilité, Age, Ethnie, Adolescent, Homme

    Mots-clés Pascal anglais : Malignant tumor, Incidence, Epidemiology, United States, North America, America, Clinical trial, Accessibility, Age, Ethnic group, Adolescent, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0077926

    Code Inist : 002B04B. Création : 14/05/1998.