Second primary extracolonic cancers in Japanese hereditary nonpolyposis colorectal cancer.
We examined the occurrence of second primary extracolonic cancers in 1,170 patients with nonpolyposis colorectal cancer who underwent a resection between 1972 and 1994.
Such cancers occurred more often in cases with hereditary nonpolyposis colorectal cancer (HNPCC) than in those without (11.1% vs. 3.6%, P=0.0286).
Five HNPCC cases developed 6 cancers in the stomach, endometrium, ovary, and ureter.
The mean interval between the first and second operation was 66 months (range : 18-153).
These findings thus indicate the importance of targetted surveillance for any second primary cancers in the upper gastrointestinal, female genital, or upper urologic tract, especially in HNPCC patients.
Mots-clés Pascal : Tumeur maligne, Côlon, Rectum, Héréditaire, Second cancer, Incidence, Grade histologique, Stade clinique, Histopathologie, Etude comparative, Japon, Asie, Epidémiologie, Homme, Appareil digestif pathologie, Intestin pathologie, Côlon pathologie, Rectum pathologie, Maladie héréditaire
Mots-clés Pascal anglais : Malignant tumor, Colon, Rectum, Hereditary, Second cancer, Incidence, Histological grading, Clinical stage, Histopathology, Comparative study, Japan, Asia, Epidemiology, Human, Digestive diseases, Intestinal disease, Colonic disease, Rectal disease, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0075646
Code Inist : 002B13B01. Création : 14/05/1998.