To determine the prevalence of hepatitis A virus (HAV) infections in children in a large urban center, a point prevalence survey was conducted using a novel, ultrasensitive assay for HAV-specific IgG in saliva.
A structured sample of 224 grade-six students (5.8% of grade registrants) was obtained from 23 schools throughout Vancouver.
All students provided saliva samples adequate for testing.
The anti-HAV prevalence rate was 7.1% (95% confidence interval, 4.1% - 11.3%). Among 167 Canadian-born students, only 5 (3%) were positive, whereas among 57 students born elsewhere, 11 (19.3%) were positive (P<. 001), with circumstances in the latter group supporting infection prior to emigration.
No clustering of positive persons was evident.
The cumulative risk of HAV infection in Canadian-born children was low through age 11-12 years even in less affluent parts of the city, speaking against a need for routine use of HAV vaccine in this setting.
Mots-clés Pascal : Virus hépatite A, Hepatovirus, Picornaviridae, Virus, Epidémiologie, Prévalence, Enfant, Homme, Milieu urbain, Canada, Amérique du Nord, Amérique, Prévention, Hépatite virale A, Virose, Infection, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Hepatitis A virus, Hepatovirus, Picornaviridae, Virus, Epidemiology, Prevalence, Child, Human, Urban environment, Canada, North America, America, Prevention, Viral hepatitis A, Viral disease, Infection, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0075507
Code Inist : 002A05C06. Création : 14/05/1998.