Airway symptoms and lung function in pipelayers exposed to thermal degradation products from MDI-based polyurethane.
Objectives-To study the prevalence of symptoms from the eyes and the upper and lower respiratory tract, lung function, and immunological sensitisation towards isocyanates in pipelayers exposed to thermal degradation products from methylene diphenyl diisocyanate (MDI) - based polyurethane (PUR).
Material and methods-50 presently active and 113 formerly active pipelayers were examined.
Also, 65 unexposed workers were investigated for comparison.
The one year prevalence of symptoms and smoking history (questionnaire data), lung function (vital capacity (VC) and forced expiratory volume in one second (FEV,), and atopy (positive skin prick tests towards standard allergens) were assessed among pipelayers and controls.
For the pipelayers, the presence of work related symptoms and estimates of isocyanate and welding exposure were obtained from an interview.
Skin prick tests towards specific isocyanate antigens and determinations of IgE-MDI and IgG-MDI in serum were also performed.
The prevalence of episodes (more than once a month) of irritative eye symptoms, congestion of the nose, and soreness or dryness in the throat was much higher among the PUR pipelayers than among the controls.
Most of the pipelayers with symptoms reported that these had started and occurred in relation to the PUR welding tasks.
Presently active pipelayers with recent high PUR exposure showed a significant reduction of FEV, compared with the controls. (...)
Mots-clés Pascal : Diphénylméthane(4,4p-diisocyanato), Soudure, Produit dégradation, Dégradation thermique, Uréthanne polymère, Toxicité, Homme, Pose pipeline, Exposition professionnelle, Médecine travail, Epidémiologie, Muqueuse, Voie respiratoire, Poumon, Appareil respiratoire pathologie, Oeil pathologie
Mots-clés Pascal anglais : Weld, Degradation product, Thermal degradation, Polyurethane, Toxicity, Human, Pipeline laying, Occupational exposure, Occupational medicine, Epidemiology, Mucosa, Respiratory tract, Lung, Respiratory disease, Eye disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0075022
Code Inist : 002B03L06. Création : 14/05/1998.