Spontaneous abortion in dry cleaning workers potentially exposed to perchloroethylene.
To investigate the association between spontaneous abortion and work within dry cleaning units in the United Kingdom where the solvent perchloroethylene is used.
Method-A retrospective occupational study of reproductive outcome in 7305 women aged 16 and 45 years, who were currently or previously employed in dry cleaning or laundry units in the United Kingdom.
Data on workplace exposures and reproductive outcome were obtained by postal survey.
A sample of reported spontaneous abortions was validated from medical records.
Machine operator versus non-operator was used as a surrogate for exposure to perchloroethylene in dry cleaning units as no data on individual doses were available for women in this study.
Result-The response rate was higher for current workers of dry cleaning units (78%), than for past workers of dry cleaning units (46%). Similarly, the response for current laundry workers (65%) was higher than that for past laundry workers (40%). Overall, the reproductive characteristics of the respondents were similar to expectation.
Examination of exposure at the time of pregnancy, however, showed that the rate of spontaneous abortion varied according to the type of work the women did during the pregnancy or in the three months before conception : being lowest for pregnancies not exposed to either dry cleaning or laundry work (10.9%), higher for those exposed to laundry work (13.4%), and higher still for those exposed to dry cleaning work (14.8%). (...)
Mots-clés Pascal : Ethylène(tétrachloro), Toxicité, Solvant organique, Industrie nettoyage, Exposition professionnelle, Médecine travail, Homme, Femme, Femelle, Royaume Uni, Europe, Epidémiologie, Avortement, Gestation pathologie, Reproduction pathologie, Nettoyage à sec
Mots-clés Pascal anglais : Ethylene(tetrachloro), Toxicity, Organic solvent, Cleaning industry, Occupational exposure, Occupational medicine, Human, Woman, Female, United Kingdom, Europe, Epidemiology, Abortion, Pregnancy disorders, Reproduction diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0075020
Code Inist : 002B03L04. Création : 14/05/1998.