We hypothesized that if prenatal caloric restriction due to nutritional deprivation had affected development of the organs responsible for producing and regulating female reproductive hormones, a woman's fertility would be impaired.
Women born in Amsterdam from August 1,1994, through April 15,1946, a period encompassing a severe 5-month famine, were identified (n=700 ; 85% response rate).
Date of birth and vital status of all offspring were ascertained by home interview between 1987 and 1991.
Famine exposure was inferred from the mother's date of birth.
Of the study participants, 74 (10,6%) had no children.
Theremainder reported 1334 offspring (1294 singletons, 20 pairs of twins), of whom 14 were stillborn and 22 died in the first 7 days of life.
There was no detectable effect of famine exposure on age at menarch, the proportion having no children, age at first delivery, or family size.
An excess of perinatal deaths occured among offspring of famine-exposed women, particularly those exposed in their third trimester.
Acute famine exposure in utero appears to have no adverse consequences for a woman's fertility.
The excess perinatal mortality in the second generation is unexplained and should be confirmed by other studies.
Mots-clés Pascal : Famine, Exposition, In utero, Fertilité, Poids naissance faible, Danemark, Europe, Carence alimentaire, Long terme, Epidémiologie, Facteur risque, Femelle, Homme, Gestation pathologie, Prématurité, Nouveau né pathologie
Mots-clés Pascal anglais : Famine, Exposure, In utero, Fertility, Low birth weight, Denmark, Europe, Nutritional deficiency, Long term, Epidemiology, Risk factor, Female, Human, Pregnancy disorders, Prematurity, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0074255
Code Inist : 002B20A03. Création : 14/05/1998.