Determinants of gamma-glutamyltransferase : Positive interaction with alcohol and body mass index, negative association with coffee.
gamma-Glutamyltransferase is widely used as a marker of alcohol intake although its performance is poor.
This might be related to other conditions influencing gamma-glutamyltransferase activity.
The authors studied determinants of gamma-glutamyltransferase activity in a random sample (n=6,010) drawn from the general population aged 25-64 years in Finland in 1992.
In regression analysis, coffee intake and drinking boiled coffee were significantly (p<0.01) negatively related to y-glutamyltransferase, whereas age, male gender, the number of cigarettes per day, serum total cholesterol and high density lipoprotein cholesterol, heart rate, and diastolic blood pressure were significantly positively related to gamma-glutamyltransferase.
A significant (p=0.02) positive interaction was observed between alcohol intake and body mass index.
In logistic regression analysis, the proportion of elevated gamma-glutamyltransferase values (=50 U/liter) was significantly decreased, compared with lifelong abstainers, at the alcohol intake level of<40 g/week (odds ratio (OR)=0.51,95% confidence interval (Cl) 0.29-0.92) and significantly increased at the level of =300 g/week (OR=2.81,95% Cl 1.35-5.85) among nonobese subjects (body mass index<27 kg/m2).
Among obese subjects, the respective proportion was significantly increased at the alcohol intake level of =40 g/week (OR=2.02,95% Cl 1.11-3.68). (...)
Mots-clés Pascal : gamma-Glutamyltransferase, Aminoacyltransferases, Transferases, Enzyme, Activité enzymatique, Prise boisson, Alcool, Café, Finlande, Europe, Tabagisme, Indice masse corporelle, Obésité, Cholestérolémie, Marqueur biologique, Métabolisme, Adulte, Homme, Etat nutritionnel, Trouble nutrition
Mots-clés Pascal anglais : gamma-Glutamyltransferase, Aminoacyltransferases, Transferases, Enzyme, Enzymatic activity, Drinking, Alcohol, Coffee, Finland, Europe, Tobacco smoking, Body mass index, Obesity, Cholesterolemia, Biological marker, Metabolism, Adult, Human, Nutritional status, Nutrition disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0074181
Code Inist : 002A16D06. Création : 14/05/1998.