The induction of chromosome aberrations, micronuclei, and sister-chromatid exchanges (SCEs) was examined in cultured lymphocytes of 27 vineyard growers exposed to pesticides.
Cytogenetic examinations were performed during the prespraying period, a month after spraying, and at the end of the spraying season.
For comparison purposes, the same cytogenetic monitoring program was applied to two control groups.
The first consisted of 15 individuals from a nearby town, and the second consisted of 20 volunteers living 200 km from the vinegrowing area (reference control group).
A positive, though low statistically significant (P<0.017) difference in the yield of unstable chromosomal aberrations in exposed sprayers was observed compared with both control groups during the prespraying period.
The mean group value of micronuclei in exposed workers averaged 5.41 per 1000 binucleated cells, with individual means ranging from 0 to 15.
In both control groups, the yield of micronuclei averaged 5.09 per 1000 binucleated cells, with individual means ranging from 1 to 10.
No statistically significant (P<0.5) differences in yield of micronuclei were found in exposed subjects compared with both control groups.
Significant individual variation (F=14.09, P<0.000) in SCE frequency was observed in exposed subjects, as well as in both control groups (F=14.09, P<0.000).
A month after spraying, the average incidence of unstable aberrations in pesticide sprayers was 0. (...)
Mots-clés Pascal : Pesticide, Exposition professionnelle, Médecine travail, Pulvérisation, Toxicité, Aberration chromosomique, Test micronucléus, Echange chromatide soeur, Viticulture, Cytogénétique, Homme, Lymphocyte
Mots-clés Pascal anglais : Pesticides, Occupational exposure, Occupational medicine, Spraying, Toxicity, Chromosomal aberration, Micronucleus test, Sister chromatid exchange, Viticulture, Cytogenetics, Human, Lymphocyte
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0065953
Code Inist : 002B03G. Création : 14/05/1998.