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  1. Carrier screening for cystic fibrosis : Test acceptance and one year follow-up.

    Article - En anglais

    We identified 124 carriers among 4,879 patients of prenatal care providers in the Rochester region.

    Six factors were identified that together permitted a correct classification regarding test acceptance for 77.5% of all subjects.

    For those pregnant, the most influential of these factors was a more accepting attitude toward abortion.

    As an indication for abortion, cystic fibrosis (CF) ranked between mild and moderate mental retardation.

    Of the 124 carrier women identified, we obtained 1-year follow-up information on 100.

    Mean score for CF knowledge at 1 year (77.4 ± 13.2%), although significantly lower than immediately after counseling (84 ± 12.4%), was still significantly higher than after detection but before counseling (51.1% ± 20.7%). Anxiety about having a child with CF significantly declined from 25.8 ± 8.0 SD immediately after counseling to 18.9 ± 7.8 at 1 year (Spielberger State Anxiety Scale).

    Although 15 carriers regretted having been tested, 83% believed that they benefited from testing, 83% would make the same decision to be tested over again, and 79% would recommend testing to a friend.

    We conclude that, for most women, CF carrier screening accomplished its purpose : most carriers detected came for counseling, had their partners tested, and, if their partners were also carriers, had prenatal diagnosis. (...)

    Mots-clés Pascal : Mucoviscidose, Dépistage, Porteur, Prénatal, Diagnostic, Epidémiologie, Intérêt, Hétérozygotie, Acceptation, Appareil respiratoire pathologie, Appareil digestif pathologie, Pancréas pathologie, Maladie héréditaire, Métabolisme pathologie

    Mots-clés Pascal anglais : Cystic fibrosis, Medical screening, Carrier, Prenatal, Diagnosis, Epidemiology, Interest, Heterozygosity, Acceptance, Respiratory disease, Digestive diseases, Pancreatic disease, Genetic disease, Metabolic diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0064154

    Code Inist : 002B23A. Création : 14/05/1998.