Dementia is a rapidly increasing health problem in the industrialized countries.
With the ageing of the population the number of demented persons increases both in relative and absolute terms.
Obviously, there is a need for prevention and intervention strategies.
We describe the methods and baseline findings of a large study aimed at identifying potentially modifiable vascular, thrombogenic, and metabolic determinants of dementia.
The study population consists of subjects 55 years of age or older.
Since the vascular wall of the cerebral vessels is different from that of the coronary or peripheral vessels, we formed three subgroups in which vascular risk factors for dementia are studied.
Subjects with stroke were distinguished from subjects with coronary or peripheral artery disease, and from subjects without stroke or coronary or peripheral artery disease.
To obtain a large enough number of subjects with stroke, cases and controls from a stroke registry were combined with cases and controls of a population-based study from the same region.
For the diagnosis of dementia the DSM-III-R criteria were used.
Extensive information on cardiovascular risk factors was collected, including indicators of atherosclerosis.
Blood and urine were sampled to study platelet function and thrombogenic and metabolic factors.
The study population consists of 7,466 subjects, of whom 300 were recruited from a hospital-based stroke registry. (...)
Mots-clés Pascal : Démence, Athérosclérose, Cardiopathie, Hémostase, Accident cérébrovasculaire, Pays Bas, Europe, Prévalence, Facteur risque, Epidémiologie, Diagnostic, Homme, Système nerveux pathologie, Trouble neurologique, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie
Mots-clés Pascal anglais : Dementia, Atherosclerosis, Heart disease, Hemostasis, Stroke, Netherlands, Europe, Prevalence, Risk factor, Epidemiology, Diagnosis, Human, Nervous system diseases, Neurological disorder, Cardiovascular disease, Vascular disease, Central nervous system disease, Cerebral disorder, Cerebrovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0063451
Code Inist : 002B17A02. Création : 14/05/1998.