Sepsis at a neonatal intensive care unit : A four-year retrospective study (1989-1992).
During the 4-year period 1989-1992,18,227 neonates were born at Kaplan Hospital and 614 (3.4%) were admitted to the neonatal intensive care unit.
During this period, 120 episodes (6.6/1000 live births) of neonatal sepsis were recorded in 109 neonates (6/1000 live births).
The incidence of early-onset sepsis was 19/109 (17%). The main pathogens of early-onset sepsis were S. agalactiae (42%) and E. coli (32%). Seven of the 8 S. agalactiae cases were recorded during 1989-1990.
The main pathogens of late-onset sepsis were Klebsiella spp. (31%), coagulase-negative staphylococci (18%) and Candida spp (16%). There were 11 cases (10%) of meningitis, 5 due to Klebsiella spp.
The overall fatality rate due to sepsis was 14% (0.8/1000 live births) with an early-onset sepsis death rate of 37%. The mortality from S. agalactiae sepsis was 63%. The main trends recorded during the period of the study were 1) the emergence of S. agalactiae as the main pathogen of early-onset sepsis, followed by a sharp decrease in its incidence during the last part of the study, 2) the emergence of extremely virulent, multi-antibiotic-resistant Klebsiella organisms, and 3) the persistent hiah incidence of Candida sepsis.
Mots-clés Pascal : Septique syndrome, Infection, Rétrospective, Incidence, Néonatal, Unité soin intensif, Facteur risque, Staphylococcus, Micrococcaceae, Micrococcales, Bactérie, Agalactie contagieuse, Mycoplasmose, Bactériose, Etiopathogénie, Klebsiella, Enterobacteriaceae, Epidémiologie, Evaluation, Nourrisson, Homme, Israël, Asie, Pédiatrie
Mots-clés Pascal anglais : Sepsis syndrome, Infection, Retrospective, Incidence, Neonatal, Intensive care unit, Risk factor, Staphylococcus, Micrococcaceae, Micrococcales, Bacteria, Contagious agalactia, Mycoplasmal infection, Bacteriosis, Etiopathogenesis, Klebsiella, Enterobacteriaceae, Epidemiology, Evaluation, Infant, Human, Israel, Asia, Pediatrics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0063020
Code Inist : 002B27B11. Création : 14/05/1998.