Drug-resistant tuberculosis (TB) has emerged as a worldwide problem.
The annual incidence of TB has increased in Israel in the last decade, mainly due to successive waves of immigration.
Few data are available on drug-resistant TB in Israel.
A 10-year retrospective review was conducted on all patients who had been infected with culture-proven Mycobacterium tuberculosis and had been admitted to our hospital.
Forty-seven patients had culture-positive TB ; 27 (57%) were male, 20 (43%) were female ; mean age (±sD) was 56±23 years.
Twenty patients (43%) had pulmonary TB.
Three patients (6.4%) had single-drug resistance ; 4 patients (8.5%) had multi-drug resistance.
Six of the seven patients (86%) with drug-resistant TB had been diagnosed after 1990.
Six of the 20 patients (30%) with pulmonary TB had drug-resistant organisms.
Six of the 7 patients (86%) with drug-resistant TB had pulmonary infection, as compared to 15/40 (37%) of the patients with drug-susceptible TB (p<0.001).
Six of the 7 patients (86%) with drug-resistant TB had a history of TB.
Fifteen percent (14.9%) of all new cases diagnosed with TB in our hospital in the last 10 years had drug-resistant M. tuberculosis.
Thirty percent of patients with pulmonary TB had drug-resistant organisms.
Drug-resistant TB has evidently emerged in Israel and poses a serious clinical and social threat.
A strong case for directly-observed treatment in Israel should be made, especially since the incidence of TB here is still small.
Mots-clés Pascal : Tuberculose, Mycobactériose, Bactériose, Infection, Epidémiologie, Complication, Résistance traitement, Etiopathogénie, Rétrospective, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bactérie, Forme clinique, Revue bibliographique, Caractéristiques, Evaluation, Homme, Israël, Asie, Antituberculeux
Mots-clés Pascal anglais : Tuberculosis, Mycobacterial infection, Bacteriosis, Infection, Epidemiology, Complication, Negative therapeutic reaction, Etiopathogenesis, Retrospective, Mycobacterium tuberculosis, Mycobacteriaceae, Mycobacteriales, Actinomycetes, Bacteria, Clinical form, Bibliographic review, Characteristics, Evaluation, Human, Israel, Asia, Antituberculous agent
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0063019
Code Inist : 002B05B02O. Création : 14/05/1998.