The effect of age on the association between body-mass index and mortality.
Background The effect of age on optimal body weight is controversial, and few studies have had adequate numbers of subjects to analyze mortality as a function of body-mass index across age groups.
Methods We studied mortality over 12 years among white men and women who participated in the American Cancer Society's Cancer Prevention Study I (from 1960 through 1972).
The 62,116 men and 262,019 women included in this analysis had never smoked cigarettes, had no history of heart disease, stroke, or cancer (other than skin cancer) at base line in 1959-1960, and had no history of recent unintentional weight loss.
The date and cause of death for subjects who died were determined from death certificates.
The associations between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and mortality were examined for six age groups in analyses in which we adjusted for age, educational level, physical activity, and alcohol consumption.
Results Greater body-mass index was associated with higher mortality from all causes and from cardiovascular disease in men and women up to 75 years of age.
However, the relative risk associated with greater body-mass index declined with age.
For example, for mortality from cardiovascular disease, the relative risk associated with an increment of 1 in the body-mass index was 1.10 (95 percent confidence interval, 1.04 to 1.16) for 30-to-44-year-old men and 1.03 (95 percent confidence interval, 1.02 to 1. (...)
Mots-clés Pascal : Indice masse corporelle, Association, Facteur risque, Mortalité, Critère âge, Etude comparative, Cardiopathie, Cancérologie, Evaluation, Homme, Métabolisme pathologie, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Body mass index, Association, Risk factor, Mortality, Age criterion, Comparative study, Heart disease, Cancerology, Evaluation, Human, Metabolic diseases, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0062962
Code Inist : 002B22E05. Création : 14/05/1998.