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  1. Seroprevalence of hepatitis A virus and Helicobacter pylori infections in the general population of a developed european country (the San Marino study) : evidence for similar pattern of spread.

    Article - En anglais

    Objective 

    To evaluate the role of faecal-oral transmission in the spread of Helicobacter pylon.

    Design 

    A cross-sectional comparison of the patterns of hepatitis A and H. pylori seropositivity.

    Methods 

    At interview, blood samples and questionnaire data were collected from a random sample of 1528 healthy subjects aged 20-85 years from the Republic of San Marino.

    Serum samples from each subject were then tested for anti-H. pylori and anti-hepatitis A antibodies.

    Results 

    Overall, 529 of 670 H. pylori-seropositive subjects (78.9%) and 460 of 858 H. pylori-seronegative subjects (53.6%) were hepatitis A seropositive (P<0.01 ; odds ratio=3.2 ; confidence interval 95%=2.6-4, i).

    This association remained after adjustment by a multiple logistic regression analysis for the confounding effect of age and length of schooling, as surrogate for socio-economic status (OR=2.0 ; CI 95%=1.3-3.3).

    The age-specific prevalence curves for H. pylori and hepatitis A infections showed a parallel increase by age, although to a lesser extent for H. pylori.

    Mots-clés Pascal : Hépatite virale A, Virose, Infection, Virus hépatite A, Hepatovirus, Picornaviridae, Virus, Gastrite, Campylobactériose, Bactériose, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Contamination, Mode transmission, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Estomac pathologie

    Mots-clés Pascal anglais : Viral hepatitis A, Viral disease, Infection, Hepatitis A virus, Hepatovirus, Picornaviridae, Virus, Gastritis, Campylobacter infection, Bacteriosis, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Contamination, Transmission mode, Epidemiology, Human, Digestive diseases, Hepatic disease, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0062735

    Code Inist : 002B05C02G. Création : 14/05/1998.