The association between serum sialic acid and asymptomatic carotid atherosclerosis is not related to antibodies to herpes type viruses or Chlamydia pneumoniae.
Total serum sialic acid is a recently investigated marker for cardiovascular mortality and carotid atherosclerosis.
This study tested the hypothesis that past infection by Herpes simplex type 1 or type 2 viruses or Cytomegalovirus ; or Chlamydia pneumoniae accounts for the association between serum total sialic acid and atherosclerosis.
Population-based samples of men and women living in four US communities were used in a cross-sectional study.
Cases and matched controls were defined by B-mode ultrasound measurements of carotid and popliteal arterial wall thickness.
In all, there were 267 case control pairs with information about antibody titres to viruses and 256 pairs with information about antibody titres to Chlamydia pneumoniae.
Serum total sialic acid (S-TSA) level was significantly higher in cases with carotid atherosclerosis compared to their controls.
The odds ratio for carotid atherosclerosis associated with sialic acid level above 75th percentile was 1.73 (95% confidence interval [Cl] : 1.02-2.95) in the sample with information about antibodies to viruses and 1.70 (95% Cl : 1.00-2.93) in the sample with information about antibodies to C. pneumoniae.
Adjustment for titres of antibodies to viruses and C. pneumoniae had no impact on the relation between sialic acid and carotid atherosclerosis. (...)
Mots-clés Pascal : Athérosclérose, Carotide, Epidémiologie, Sialique acide, Facteur risque, Anticorps, Herpesviridae, Virus, Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bactérie, Antécédent, Infection, Homme, Suède, Europe, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Atherosclerosis, Carotid, Epidemiology, Sialic acid, Risk factor, Antibody, Herpesviridae, Virus, Chlamydia pneumoniae, Chlamydiaceae, Chlamydiales, Bacteria, Antecedent, Infection, Human, Sweden, Europe, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0056884
Code Inist : 002B12B01. Création : 14/05/1998.