To describe the relationship between absolute CD4 count and CD4%, and the influence on this of gender, risk group, age, a diagnosis of AIDS, use of zidovudine (ZDV) therapy and PCP prophylaxis.
9203 paired serial measurements of CD4 count and CD4% on 1017 initially AIDS-free and ZDV-naive HIV positive patients from a London-based cohort were available for analysis.
Multi-level regression procedures were used on log-transformed data to relate values of CD4 count to a given level of CD4%. We estimated the effect of selected covariates on this relationship from the exponent of the covariate coefficient.
A strong linear relationship was found between log CD4 and log CD4%. CD4=e 1.78 (CD4%1.26 or 5.93 (CD4%) 1.26 (excluding covariates).
Based on this model, a CD4% of 5%, 15%, and 30% corresponded to an estimated CD4 count (95% confidence interval [Cl]) of 45 cells/mm3 (17-117 cells/mm3), 182 celts/mm3 (64-499 cells/mm3) and 438 cells/mm3 (132-1395 cells/mm3), respectively.
However, after adjustment for selected covariates, the predicted CD4 count for a given CD4% was found to be lower among heterosexuals and injecting drug users as compared with homosexual men by 30% and 17% respectively ; following an AIDS diagnosis by 21% ; and after initiation of ZDV therapy and PCP prophylaxis by 19% and 10%, respectively. (...)
Mots-clés Pascal : Numération, Lymphocyte, Cytométrie flux, Surveillance biologique, Homme, SIDA, Virose, Infection, Facteur prédictif, Etude comparative, Technique, Age, Sexe, Chimiothérapie, Traitement, Diagnostic, Immunopathologie, Immunodéficit, Antigène CD4
Mots-clés Pascal anglais : Numeration, Lymphocyte, Flow cytometry, Biological monitoring, Human, AIDS, Viral disease, Infection, Predictive factor, Comparative study, Technique, Age, Sex, Chemotherapy, Treatment, Diagnosis, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0056882
Code Inist : 002B05C02D. Création : 14/05/1998.