S-p-toluylmercapturic acid in the urine of workers exposed to toluene : a new biomarker for toluene exposure.
A mercapturic acid attached to the aromatic ring of toluene was for the first time detected in human urine as a metabolite of toluene.
Since the metabolism of toluene is usually considered to take place at the side-chain, this gives, besides the biosynthesis of cresols, a further hint of a metabolic conversion of the aromatic system.
We examined a group of 33 workers occupationally exposed to toluene, determining the concentrations of toluene in ambient air and in whole blood, o-cresol and hippuric acid in urine and p-toluylmercapturic acid (p-TMA) in urine.
All blood and urine samples were collected post-shift.
The renal excretion of S-p-toluylmercapturic acid showed highly significant correlations with established parameters of a biological monitoring of toluene.
The median ambient air concentration was 63 ppm, ranging from 13 to 151 ppm, the median concentration of toluene in whole blood was 804 mug/l, corresponding to median urinary concentrations for o-cresol of 2.3 mg/l, hippuric acid of 2.3 g/l and p-TMA of 20.4 mug/I. p-TMA was not detectable in urine samples of a control group of 10 non-exposed persons.
Both the German Biological Tolerance Values (BAT-values) for toluene in blood (1000 mug/I) and o-cresol in urine (3 mg/I) correspond to a mean p-TMA elimination of mw50 mug/I, and thus are in agreement with each other.
According to our results p-TMA reflects internal toluene exposure diagnostically sensitive and specifical. (...)
Mots-clés Pascal : Toluène, Solvant organique, Exposition professionnelle, Médecine travail, Homme, Surveillance biologique, Marqueur biologique, Urine, Liquide biologique, Mercapturique acide dérivé
Mots-clés Pascal anglais : Toluene, Organic solvent, Occupational exposure, Occupational medicine, Human, Biological monitoring, Biological marker, Urine, Biological fluid
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0056671
Code Inist : 002B03L04. Création : 14/05/1998.